Poly(A)-specific ribonuclease (PARN), a multifunctional multi-domain deadenylase, is crucial to the regulation of mRNA turnover and the maturation of various non-coding RNAs.Despite extensive studies of the well-folding domains responsible for PARN catalysis, the structure and function of the C-terminal domain (CTD) remains elusive.PARN is a cytopl
Reconstitution of human PDAC using primary cells reveals oncogenic transcriptomic features at tumor onset
Abstract Animal studies have demonstrated the ability of pancreatic acinar cells to transform into pancreatic ductal adenocarcinoma (PDAC).However, the tumorigenic potential of human pancreatic acinar cells remains under debate.To address this gap in knowledge, we expand sorted human acinar cells as 3D organoids Cutting Boards and genetically modif
Enhancing Cinema Evacuation Efficiency: Impact of Flashing Lights on Emergency Egress Performance and Fire Safety
Evacuation lighting is a crucial component of cinema safety, significantly impacting operational safety and evacuation efficiency.It plays a key role in enhancing evacuation measures and ensuring the safety of cinema patrons.An experiment utilizing virtual reality technology was conducted at Beijing Forestry University with 62 subjects randomly ass
Baltic Sea shipwrecks as a source of hazardous pollution
Background Shipwrecks on the Baltic Sea seabed pose a serious threat to the marine environment.Fuel, ammunition and chemicals in their holds can enter the ecosystem at any time, causing an ecological disaster.It is known that oil spills from ship accidents can affect life and health of different species of animals, both immediately after catastroph